Ad5 Immune Complexes May Improve HIV Replication
NEW YORK (Reuters Health) Nov 17 - Activation of a dendritic cell T-cell axis by adenovirus type 5 (Ad5) immune complex appears to trigger the process that led to the premature termination of the STEP Ad5 HIV vaccine trial in 2007, European researchers report in an a November 3rd on-line publication in the Journal of Experimental Medicine.
“Our observations may help to explain the increased acquisition of HIV-1 infection and the reduced magnitude of HIV-specific CD8 T-cell responses observed in the STEP trial among the Ad5 seropositive vaccine recipients,” senior investigator Dr. Eric J. Kremer told Reuters Health.
Dr. Kremer of Centre National de la Recherche Scientifique Montpellier, France and colleagues studied the effect of Ad5 vector alone or Ad5 immune complexes on dendritic cells.
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