The Karmanos Cancer Institute made an investment in funding new pilot projects and awarded $25,000 each to 16 internal Strategic Research Initiative Grant new pilot projects. These projects involve more than 30 Karmanos members from various research programs. The funding began on July 1, 2009 for a period of one year. The projects funded are listed alphabetically by title below.

Project Title Principal Investigator(s) A Systems Biology Approach to Identify Novel Mechanisms Linking Epigenetic Regulation, Cell Proliferation, Tumor Progression and Aging Lori Pile, Ph.D. Ahmad Heydari, Ph.D. Accuracy of the CancerGene Program to Estimate the Probability of a BRCA1/2 Mutation: Effect of Limited Family Structure Michael Simon, M.D. Are Observational Coding Systems of Trust in Breast Oncology Interactions Culturally Sensitive? Donyell Coleman, Ph.D. Sharon Mills-Wisneski, DNSc Kelly Brittain, M.S.N. DCE-MRI Imaging to Monitor Vascular Changes and Therapeutic Efficacy Induced by Combined Modalities for Murine Renal Cell Carcinoma Gilda Hillman, Ph.D. Mark Haacke, Ph.D. Lung Cancer and Bone Metastases Shirish Gadgeel, M.D. Fulvio Lonardo, M.D. Modulation of inducible regulatory T cells (iTreg) in cancer immunotherapy Venuprasad Poojary, Ph.D. Wei-zen Wei, Ph.D. Non-invasive Assessment of Tumor Cell Viability In Vivo Rod Braun, Ph.D.Bruce Berkowitz, Ph.D. Oncogene Profiling of Lung Cancers: Insight into the leading cause of cancer deaths Michele Cote, Ph.D. Ramsi Haddad, Ph.D. Patient Determinants of Non-Adherence to Phase II and III Oral Cancer Therapy Felicity Harper, Ph.D. Louis Penner, Ph.D. Elisabeth Heath, M.D. Prostate Cancer Proteasome as a Novel Molecular Target of Metal Complexes: Synthesis and Biological Validation in vitro and in vivo Claudio Verani, Ph.D. Q. Ping Dou, Ph.D. Protease Signaling on the Cell-Surface of Breast Cancer Cells: Role of Matriptase Mediated Activation of the Proto-Oncogene c-Met Julie Boerner, Ph.D. Karin List, Ph.D. Roles of Endoplasmic Reticulum Factor ERLIN2 in Malignancy Maintenance and Therapy Resistance in Breast Cancer Zeng-Quan Yang, Ph.D. Kezhong Zhang, Ph.D. Synthetic Genetic Interactions & Cancer Therapy George Brush, Ph.D. Russell Finley Jr., Ph.D. The Cancer Palmitoyl-Proteome Nicholas Davis, Ph.D. Raymond Mattingly, Ph.D. The Potential for Therapeutic Targeting Malignant Pleural Mesothelioma with PCFT-targeted cytotoxins Larry Matherly, Ph.D. John Graff, Ph.D. The Role of Iroquis homeobox gene 4 in Breast Cancer Tumorigenesis and Metastasis Guojun Wu, Ph.D.

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1. New Internal Pilot Projects Funded

BUFFALO, NY – Mimi Haskins, MS, RN, CMSRN, a member of the Nursing Staff Development Department at Roswell Park Cancer Institute (RPCI), has been selected to serve on the Board of Directors for the Medical-Surgical Nursing Certification Board (MSNCB). She will assume her role in September 2009.

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BUFFALO, NY – Trusted health care sources and continuity of care may help reduce the risk of prostate cancer deaths in African-American men, according to a study published in the current issue of the journal Cancer. James Mohler, MD, Chair of the Department of Urology at Roswell Park Cancer Institute (RPCI), and William R. Carpenter, PhD, Department of Health Policy and Management at the University of North Carolina, are lead investigators.

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LITTLE ROCK – People of all ages are invited to register for the Eighth Annual Village Walk for Cancer Research on Sept. 19 in Hot Springs Village. One hundred percent of proceeds from the walk will benefit the Winthrop P. Rockefeller Cancer Institute at the University of Arkansas for Medical Sciences (UAMS).

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BUFFALO, NY – The National Cancer Institute has awarded a five-year, $2.8 million Research Project (RO1) grant to Roswell Park Cancer Institute (RPCI) researchers to investigate the role of immunological pathways in the development of ovarian cancer.

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1. Emory Launches “Health Now” Blog

Atlanta - Cynthia Anderson, MD has joined Emory University's Department of Radiation Oncology as an assistant professor. 

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ATLANTA - Seven cancer researchers at Emory University are among the 19 selected as Distinguished Cancer Clinicians and Scientists by the Georgia Cancer Coalition for 2009-10. Emory's new Distinguished Cancer Scholars include:

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1. Nanoparticles Could Improve Breast Cancer Diagnosis Via MRI

BUFFALO, NY – Roswell Park Cancer Institute (RPCI) will host “Sarcoma Awareness Gone Wild” on Sunday, July 26, 10 am – 5 pm at the Buffalo Zoo. The event is part of the worldwide Team Sarcoma Initiative designed to raise awareness about sarcoma, a rare cancer of the connective tissues.

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