Rare Peptide Segments Are Found Significantly More Often In Proto-Oncoproteins Than Control Proteins: Implications For Immunology And Oncology

There is some evidence to suggest that peptide segments that are found rarely or never in the host proteome play a role in the immune response to disease-related proteins, both those derived from microbes and those derived from the host itself.

We conjecture that this pattern may extend to human proto-oncoproteins. Our hypothesis in this study is that the frequency of rare peptide segments in sets of human proto-oncoproteins is significantly higher than the frequency in sets of control proteins, and we show that this is the case.

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1. Rare Peptide Segments Are Found Significantly More Often In Proto-Oncoproteins Than Control Proteins: Implications For Immunology And Oncology